Emphascience, Inc.

Reformulated Products

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Why reformulate? Pharmaceutical R&D productivity is stifled by the staggering cost (ca. $1 billion), damaging odds of success (<10% in the clinic), and time (>13 years) to develop one new molecular entity. Optimized formulations of approved drugs being developed by Emphascience, on the other hand, can offer new therapeutic applications, market exclusivity and brand differentiation in as little as 30 months and at an insignificant fraction of the cost.

Unstable Injections

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Global injection drug market is estimated to be >$240 billion, or 28% of the overall drug market. Emphascience is particularly adept at reformulating injections to make them more stable and easy to use.

Poorly Soluble Drugs

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An estimated 40% of approved drug molecules and 90% of those under development are poorly soluble, and at least half suffer from low bioavailability. Emphascience is making strides into this >$60 billion worth of reformulation and market opportunity.

Cytotoxic Drugs

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Global market for oncology drugs and supportive therapy is >$100 billion. Emphascience is developing safe, ready-to-administer injections for cytotoxic drugs to minimize the risk of accidental exposure to nurses and physicians.

Dose Adjustments

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Pharmacy compounding customizes doses or addresses patient-specific needs. This $5 billion practice is linked to hundreds of injuries and >50 accidential deaths in the past two decades. Emphascience is designing products that are simple to adjust, eliminate error and the need for customization by pharmacies.

Dosing and Compliance

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Non-adherence to therapy averages nearly 50% in patients of all ages, and is even higher among the elderly. Emphascience is leveraging its expertise to develop long-acting drugs, combination products, and to select the optimum route of administration to simplify dosing and improve compliance.

Safer Excipients

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Despite no demonstrated impact on human health and safety at the permissible levels of use, many antioxidants, chelators and preservatives used in pharmaceutical products have cytotoxic, teratogenic, and carcinogenic potential at pronounced levels. Emphascience applies its knowhow on drug molecule stability to eliminate antioxidants and chelators from many existing product formulations without compromising product quality and performance.

Innovations for Better Medicines

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